Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.

Dataset

identifier:	1842129
description:	epitope description:alpha-D-Manp-(1->2)-alpha-D-Manp antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:2G12
aggregation:	instance of dataset
availability:	available
primaryPublications:	12829775

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019582
landingPage:	http://www.iedb.org/assay/1842129

Publication

type:	Literature
publicationVenue:	Science
dates:	2003

Dimension

study type:	b cell assays
subject species:	Human immunodeficiency virus 1

Person

fullName:	Daniel A Calarese Christopher N Scanlan Michael B Zwick Songpon Deechongkit Yusuke Mimura Renate Kunert Ping Zhu Mark R Wormald Robyn L Stanfield Kenneth H Roux Jeffery W Kelly Pauline M Rudd Raymond A Dwek Hermann Katinger Dennis R Burton Ian A Wilson

Data Type

method:	x-ray crystallography

Study

name:	Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.
description:	The crystal structure of Fab 2G12 bound to the epitope was determined. The asymmetric unit contains two Fab molecules that form a tightly packed dimer via a three-dimensional swap of their VH domains. This dimeric assembly is not observed in over 250 Fab structures deposited in the Protein Data Bank.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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