Double reactivity of monoclonal and polyclonal rheumatoid factors for IgG and histones: mapping of binding sites by means of histone synthetic peptides and anti-Id antibodies.

Title:

Double reactivity of monoclonal and polyclonal rheumatoid factors for IgG and histones: mapping of binding sites by means of histone synthetic peptides and anti-Id antibodies.

Dataset

identifier:	1843062
description:	epitope description:ARTKQTARKSTGGKAPRKQLA antigen name:Histone H3.1 host organism:Homo sapiens antibody name:RF
aggregation:	instance of dataset
availability:	available
primaryPublications:	1373058

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014698
landingPage:	http://www.iedb.org/assay/1843062

Publication

type:	Literature
publicationVenue:	J Autoimmun
dates:	1992

Dimension

study type:	b cell assays
subject species:	Bos taurus

Person

fullName:	N Tuaillon A M Knapp J L Pasquali S Muller

Data Type

method:	ELISA

Study

name:	Double reactivity of monoclonal and polyclonal rheumatoid factors for IgG and histones: mapping of binding sites by means of histone synthetic peptides and anti-Id antibodies.
description:	The epitope sequence is from an author communication for the reference cited: Muller et al. (1989) Int Arch Allergy Appl Immunol 89: 5288-296 [PMID: 2474514]. Purified RF from 2 patients tested that reacted with histones reacted with the epitope. The epitope inhibited RF binding by 44% to histone for 1 of the 2 samples. The epitope partially (38%) inhibited 1 of 2 RF samples tested from binding to Ig. The epitope inhibited that RF binding to the epitope by 73%.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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