Double reactivity of monoclonal and polyclonal rheumatoid factors for IgG and histones: mapping of binding sites by means of histone synthetic peptides and anti-Id antibodies.

Title:

Double reactivity of monoclonal and polyclonal rheumatoid factors for IgG and histones: mapping of binding sites by means of histone synthetic peptides and anti-Id antibodies.

Dataset

identifier:	1842173
description:	epitope description:KPKAAKPKKAAAKKK antigen name:Histone H1.4 host organism:Homo sapiens antibody name:RF
aggregation:	instance of dataset
availability:	available
primaryPublications:	1373058

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1014698
landingPage:	http://www.iedb.org/assay/1842173

Publication

type:	Literature
publicationVenue:	J Autoimmun
dates:	1992

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	N Tuaillon A M Knapp J L Pasquali S Muller

Data Type

method:	ELISA

Study

name:	Double reactivity of monoclonal and polyclonal rheumatoid factors for IgG and histones: mapping of binding sites by means of histone synthetic peptides and anti-Id antibodies.
description:	The epitope sequence is from the reference cited: Ohe et al. (1986) J Biochem 100: 359-368 [PMID: 3782055]. Purified RF from 2 of 2 patients tested that reacted with histones reacted with the epitope. However, the epitope did not inhibit RF binding to histone. The epitope did not inhibited 2 RF samples tested from binding to Ig and Ig partially (48%) inhibited 1 of 2 RF samples from binding to the epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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