Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet v 1.

Title:

Dataset

identifier:	1845110
description:	epitope description:EVDHTNFKYNYSVIEGGPIGDTLEKISNEIK antigen name:Bet v 1 host organism:Oryctolagus cuniculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	21451110

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1021980
landingPage:	http://www.iedb.org/assay/1845110

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2011

Dimension

study type:	b cell assays
subject species:	Betula pendula

Person

fullName:	Anna Gieras Petra Cejka Katharina Blatt Margarete Focke-Tejkl Birgit Linhart Sabine Flicker Angelika Stoecklinger Katharina Marth Anja Drescher Josef Thalhamer Peter Valent Otto Majdic Rudolf Valenta

Data Type

method:	biological activity

Study

name:	Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet v 1.
description:	Preincubation with anti-epitope specific polyclonal Abs resulted in a strong downregulation of CD203c expression in basophils induced by Bet v 1 in patients allergic to birch pollen.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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