Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1845947 |
| description: |
epitope description:S314, E316, K317, F318, P319, Q327, L328, V329, C330, W331, Q332, A333, T335, P337, I340, T375, D378, C380
antigen name:Beta-secretase 1
host organism:Homo sapiens
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21613622 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022165 |
| landingPage: |
http://www.iedb.org/assay/1845947 |
| type: |
Literature
|
| publicationVenue: |
Sci Transl Med
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Jasvinder K Atwal
Yongmei Chen
Cecilia Chiu
Deborah L Mortensen
William J Meilandt
Yichin Liu
Christopher E Heise
Kwame Hoyte
Wilman Luk
Yanmei Lu
Kun Peng
Ping Wu
Lionel Rouge
Yingnan Zhang
Robert A Lazarus
Kimberly Scearce-Levie
Weiru Wang
Yan Wu
Marc Tessier-Lavigne
Ryan J Watts
|
| method: |
biological activity
|
| name: |
A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo.
|
| description: |
Adoptive transfer of epitope specific anti-BACE1 (Yw412.8.31) into mice was shown to inhibit BACE1 enzymatic activity in vivo by the reduction in plasma and forebrain Aß 1-40 levels, in a dose-dependent manner.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
