Fine epitope mapping of monoclonal antibodies against hemagglutinin of a highly pathogenic H5N1 influenza virus using yeast surface display.

Title:

Fine epitope mapping of monoclonal antibodies against hemagglutinin of a highly pathogenic H5N1 influenza virus using yeast surface display.

identifier:	1845965
description:	epitope description:R224 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:H5-2A
aggregation:	instance of dataset
availability:	available
primaryPublications:	21569761

study type:	b cell assays
subject species:	Influenza A virus (A/Viet Nam/1203/2004(H5N1))

fullName:	Thomas Han Jianhua Sui Andrew S Bennett Robert C Liddington Ruben O Donis Quan Zhu Wayne A Marasco

method:	flow cytometry

name:	Fine epitope mapping of monoclonal antibodies against hemagglutinin of a highly pathogenic H5N1 influenza virus using yeast surface display.
description:	The epitope was deduced. The epitope was deduced by loss of binding when the HA protein molecule was mutated at the epitopic residues. The epitope specific mAb bound to yeast-displayed HA0 and HA1 but not to HA2 and the mAb also bound to heat-denatured HA1 on yeast.

name:	iedb
homePage:	http://www.iedb.org

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