Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.

Dataset

identifier:	1846595
description:	epitope description:C118, V119, L121, V196, T198, Q199, R406, K408, Q409, I410, M421, P424 antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:17b
aggregation:	instance of dataset
availability:	available
primaryPublications:	11188697

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1089
landingPage:	http://www.iedb.org/assay/1846595

Publication

type:	Literature
publicationVenue:	Structure
dates:	2000

Dimension

study type:	b cell assays
subject species:	Human immunodeficiency virus type 1 (isolate YU2)

Person

fullName:	P D Kwong R Wyatt S Majeed J Robinson R W Sweet J Sodroski W A Hendrickson

Data Type

method:	x-ray crystallography

Study

name:	Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.
description:	The epitope residues are calculated from the PDB structure [PDB: 1G9N] as the antigen residues at 4 Å distance from the antibody. The epitope for the monoclonal Fab was determined by the crystal structure of the Fab with gp120 core and two-domain CD4 (d1d2). The GP120 core protein had Gly-Ala-Gly tri-peptide substitutions for the V1/V2 and V3 loop regions.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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