Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1849720 |
| description: |
epitope description:R134, R152, S154, S156, S162, R170, Y172, H173, Y174, R175, V205, D207, G208, L209, I210
antigen name:Tyrosine-protein kinase ABL1
host organism:Homo sapiens
antibody name:HA4
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
20357770 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022196 |
| landingPage: |
http://www.iedb.org/assay/1849720 |
| type: |
Literature
|
| publicationVenue: |
Nat Struct Mol Biol
|
| dates: |
2010
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
John Wojcik
Oliver Hantschel
Florian Grebien
Ines Kaupe
Keiryn L Bennett
John Barkinge
Richard B Jones
Akiko Koide
Giulio Superti-Furga
Shohei Koide
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.
|
| description: |
Epitope residues are calculated from the structure [PDB: 3K2M] as the antigen residues at 4 Å
distance from the antibody.
The epitope-specific monobody HA4 bound to the Abl SH2 domain with high affinity.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
