Natural mouse and human antibodies bind to a peptide derived from a germline VH chain. Evidence for evolutionary conserved self-binding locus.

Title:

Natural mouse and human antibodies bind to a peptide derived from a germline VH chain. Evidence for evolutionary conserved self-binding locus.

identifier:	1847869
description:	epitope description:phosphocholine host organism:Mus musculus BALB/c antibody name:T15 (TEPC15)
aggregation:	instance of dataset
availability:	available
primaryPublications:	2124238

study type:	b cell assays
subject species:

fullName:	S V Kaveri C Y Kang H Kö hler

method:	antigen inhibition

name:	Natural mouse and human antibodies bind to a peptide derived from a germline VH chain. Evidence for evolutionary conserved self-binding locus.
description:	The peptide, derived from the T15 heavy chain variable region, inhibited the binding of epitope-specific mAb T15 to the peptide, which reflects the self-binding property of T15. The intact antibody T15 also inhibited the binding of T15 to the peptide. T15 was shown to directly bind the T15 peptide conjugated to BSA.

name:	iedb
homePage:	http://www.iedb.org

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