Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.

Title:

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.

identifier:	1847901
description:	epitope description:SAQSQRAPDR antigen name:Immunoglobulin host organism:Mus musculus BALB/c antibody name:H47H4
aggregation:	instance of dataset
availability:	available
primaryPublications:	20458139

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Hans D Brightbill Surinder Jeet Zhonghua Lin Donghong Yan Meijuan Zhou Martha Tan Allen Nguyen Sherry Yeh Donnie Delarosa Steven R Leong Terence Wong Yvonne Chen Mark Ultsch Elizabeth Luis Sree Ranjani Ramani Janet Jackman Lino Gonzalez Mark S Dennis Anan Chuntharapai Laura DeForge Y Gloria Meng Min Xu Charles Eigenbrot Wyne P Lee Canio J Refino Mercedesz Balazs Lawren C Wu

method:	flow cytometry

name:	Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.
description:	The epitope specific mouse mAb 47H4 and humanized H47H4 bound to Daudi cells transfected with IgE with M1' but not to cells transfected with IgE lacking M1'. H47H4 also bound to U266 myeloma cells naturally expressing membrane IgE.

name:	iedb
homePage:	http://www.iedb.org

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