Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1847946 |
| description: |
epitope description:C118, V119, L121, V196, T198, Q199, A200, C201, R406, I407, K408, Q409, I410, M421, P424
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:17b
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
18619974 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1019670 |
| landingPage: |
http://www.iedb.org/assay/1847946 |
| type: |
Literature
|
| publicationVenue: |
J Mol Biol
|
| dates: |
2008
|
| study type: | b cell assays |
| subject species: | Human immunodeficiency virus type 1 (isolate YU2) |
| fullName: |
Franç
ois Stricher
Chih-chin Huang
Anne Descours
Sophie Duquesnoy
Olivier Combes
Julie M Decker
Young Do Kwon
Paolo Lusso
George M Shaw
Claudio Vita
Peter D Kwong
Loï
c Martin
|
| method: |
x-ray crystallography
|
| name: |
Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein.
|
| description: |
The epitope residues are calculated from the PDB structure [PDB: 2I5Y] as the antigen residues at 4 Å
distance from the antibody.
The crystal structure of epitope-specific monoclonal antibody bound to GP120 core (HIV YU2 isolate) and the CD4 mimetic peptide was determined. The GP120 core protein had Gly-Ala-Gly tri-peptide substitutions for the V1/V2 and V3 loop regions. The scorpion toxin mimic of CD4 (CD4M47) contained beta-mercaptopropionic acid at position 1, (R)-2-amino-3-(4-phenylcyclohexyl) propanoic acid at position 23 and valinylamine at position 27. There are no direct contacts of 17b Fab with CD4M47.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
