Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1848131 |
| description: |
epitope description:A281, T283, S365, G366, G367, D368, P369, E370, I371, V372, T373, Y384, R419, K421, N425, M426, G473, D474
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:b13
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
19965434 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022139 |
| landingPage: |
http://www.iedb.org/assay/1848131 |
| type: |
Literature
|
| publicationVenue: |
Science
|
| dates: |
2009
|
| study type: | b cell assays |
| subject species: | HIV-1 M:B_HXB2R |
| fullName: |
Lei Chen
Young Do Kwon
Tongqing Zhou
Xueling Wu
Sijy O'Dell
Lisa Cavacini
Ann J Hessell
Marie Pancera
Min Tang
Ling Xu
Zhi-Yong Yang
Mei-Yun Zhang
James Arthos
Dennis R Burton
Dimiter S Dimitrov
Gary J Nabel
Marshall R Posner
Joseph Sodroski
Richard Wyatt
John R Mascola
Peter D Kwong
|
| method: |
biological activity
|
| name: |
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
|
| description: |
The epitope residues are calculated from the PDB structures [PDB: 3IDX, 3IDY] as the antigen residues at 4 Å
distance from the antibody. The structures (determined in different space groups) give slightly different epitopes: [PDB: 3IDX] gives A281, T283, S365, G366, G367, D368, P369, E370, I371, V372, T373, Y384, R419, K421, N425, D474
while [PDB: 3IDY] gives S365, G366, G367, D368, P369, E370, I371, T373, W375, Y384, R419, K421, N425, M426, G473, D474. The combined epitope is provided here. Contact residue W375 is a Ser residue in the natural sequences in GenBank.
The epitope-specific monoclonal antibody neutralized HIV clade B viruses including HXB2, MN.3, SF162, ADA, BaL.01, BaL.26, SS1196.1, JR-FL and 6535.3, but not most tier 2/clade B or clade C viruses.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
