Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1848621 |
| description: |
epitope description:N280, A281, S365, G366, G367, D368, P369, I371, V372, T373, Y384, N386, P417, R419, V430, G431, K432, T455, R456, G472, G473, D474, M475
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:b12
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
17301785 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022128 |
| landingPage: |
http://www.iedb.org/assay/1848621 |
| type: |
Literature
|
| publicationVenue: |
Nature
|
| dates: |
2007
|
| study type: | b cell assays |
| subject species: | HIV-1 M:B_HXB2R |
| fullName: |
Tongqing Zhou
Ling Xu
Barna Dey
Ann J Hessell
Donald Van Ryk
Shi-Hua Xiang
Xinzhen Yang
Mei-Yun Zhang
Michael B Zwick
James Arthos
Dennis R Burton
Dimiter S Dimitrov
Joseph Sodroski
Richard Wyatt
Gary J Nabel
Peter D Kwong
|
| method: |
x-ray crystallography
|
| name: |
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
|
| description: |
The epitope residues are calculated from the PDB structure [PDB: 2NY7] as antigen residues at 4 Å
distance from the antibody.
The epitope of Fab b12 antibody on the stabilized gp120 core (Ds12 F123) was determined from the crystal structure of the complex. The stabilized HIV gp120 core (Ds12 F123) had substitutions M95W, W96C, I109C, T257S, V275C, S334A, S375W, Q428C, A433M, as well as Gly-Ala-Gly tri-peptide substitutions for the V1/V2 and V3 loop regions.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
