Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.

Title:

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.

identifier:	1848912
description:	epitope description:C119, V120, L122, T202, Q203, R419, K421, Q422, I423, M434, P437 antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:17b
aggregation:	instance of dataset
availability:	available
primaryPublications:	14981267

study type:	b cell assays
subject species:	HIV-1 M:B_HXB2R

fullName:	Chih-chin Huang Miro Venturi Shahzad Majeed Michael J Moore Sanjay Phogat Mei-Yun Zhang Dimiter S Dimitrov Wayne A Hendrickson James Robinson Joseph Sodroski Richard Wyatt Hyeryun Choe Michael Farzan Peter D Kwong

method:	x-ray crystallography

name:	Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.
description:	The epitope residues are calculated from the PDB structure [PDB: 1RZJ] as the antigen residues at 4 Å distance from the antibody. The epitope of the monoclonal antibody on HIV gp120 core bound to 2-domain CD4 was determined from the crystal structure of the complex.

name:	iedb
homePage:	http://www.iedb.org

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