Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1850154 |
| description: |
epitope description:C119, V120, L122, V200, T202, Q203, A204, C205, R419, K421, Q422, I423, M434, P437
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:17b
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
17301785 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022128 |
| landingPage: |
http://www.iedb.org/assay/1850154 |
| type: |
Literature
|
| publicationVenue: |
Nature
|
| dates: |
2007
|
| study type: | b cell assays |
| subject species: | HIV-1 M:B_HXB2R |
| fullName: |
Tongqing Zhou
Ling Xu
Barna Dey
Ann J Hessell
Donald Van Ryk
Shi-Hua Xiang
Xinzhen Yang
Mei-Yun Zhang
Michael B Zwick
James Arthos
Dennis R Burton
Dimiter S Dimitrov
Joseph Sodroski
Richard Wyatt
Gary J Nabel
Peter D Kwong
|
| method: |
x-ray crystallography
|
| name: |
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
|
| description: |
The epitope residues are calculated from the PDB structures [PDB: PDB 2NXY, 2NXZ, 2NY0, 2NY1, 2NY2, 2NY3, 2NY4, 2NY5, 2NY6] as antigen residues at 4Å
distance from the antibody.
The epitope of Fab 17b on the gp120 core (K231C, T257S, E268C, S334A, S375W) complexed with CD4 was determined from the crystal structure of the complex. The gp120 core protein had Gly-Ala-Gly tri-peptide substitutions for the V1/V2 and V3 loop regions.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
