Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responses.

Title:

Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responses.

identifier:	1850187
description:	epitope description:sialic acid antigen name:Leukosialin host organism:Rattus norvegicus antibody name:S7
aggregation:	instance of dataset
availability:	available
primaryPublications:	20106975

study type:	b cell assays
subject species:	Mus musculus

fullName:	Leonardo Freire-de-Lima Frederico Alisson-Silva Sebastiã o T Carvalho Christina M Takiya Maurí cio M Rodrigues George A DosReis Lucia Mendonç a-Previato José O Previato Adriane R Todeschini

method:	flow cytometry

name:	Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responses.
description:	The epitope-specific mAb stained CD8+ T cells purified from C57BL/6 mice. Cells purified from mice lacking the ST3Gal-I sialyltransferase, an enzyme required for sialylation of core 1 O-glycans, showed decreased binding by the mAb, compared to cells from wildtype mice.

name:	iedb
homePage:	http://www.iedb.org

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