A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.

Title:

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.

identifier:	1854112
description:	epitope description:P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382 antigen name:Proprotein convertase subtilisin/kexin type 9 host organism:Homo sapiens antibody name:1D05
aggregation:	instance of dataset
availability:	available
primaryPublications:	20959675

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Yan G Ni Stefania Di Marco Jon H Condra Laurence B Peterson Weirong Wang Fubao Wang Shilpa Pandit Holly A Hammond Ray Rosa Richard T Cummings Dana D Wood Xiaomei Liu Matthew J Bottomley Xun Shen Rose M Cubbon Sheng-ping Wang Douglas G Johns Cinzia Volpari Lora Hamuro Jayne Chin Lingyi Huang Jing Zhang Zhao Salvatore Vitelli Peter Haytko Douglas Wisniewski Lyndon J Mitnaul Carl P Sparrow Brian Hubbard Andrea Carfí Ayesha Sitlani

method:	surface plasmon resonance (SPR)

name:	A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.
description:	The binding kinetics of epitope-specific 1D05 Fab for rhesus PCSK9 was determined by SPR.

name:	iedb
homePage:	http://www.iedb.org

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