Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1854119 |
| description: |
epitope description:P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
antigen name:Proprotein convertase subtilisin/kexin type 9
host organism:Homo sapiens
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
20959675 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1021245 |
| landingPage: |
http://www.iedb.org/assay/1854119 |
| type: |
Literature
|
| publicationVenue: |
J Lipid Res
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Yan G Ni
Stefania Di Marco
Jon H Condra
Laurence B Peterson
Weirong Wang
Fubao Wang
Shilpa Pandit
Holly A Hammond
Ray Rosa
Richard T Cummings
Dana D Wood
Xiaomei Liu
Matthew J Bottomley
Xun Shen
Rose M Cubbon
Sheng-ping Wang
Douglas G Johns
Cinzia Volpari
Lora Hamuro
Jayne Chin
Lingyi Huang
Jing Zhang Zhao
Salvatore Vitelli
Peter Haytko
Douglas Wisniewski
Lyndon J Mitnaul
Carl P Sparrow
Brian Hubbard
Andrea Carfí
Ayesha Sitlani
|
| method: |
biological activity
|
| name: |
A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.
|
| description: |
A single injection of epitope-specific 1D05-IgG2 into rhesus monkeys reduced the level of circulating low-density lipoprotein cholesterol (LDLc) by up to 50%.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
