Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1852186 |
| description: |
epitope description:A: K243, D246, P248, L249, N250, P380, Q381, Y382, H383; B: I231, H234, E235
antigen name:H(+)/Cl(-) exchange transporter ClcA
host organism:Mus musculus
antibody name:10EC3/G4
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
18678918 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1019693 |
| landingPage: |
http://www.iedb.org/assay/1852186 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2008
|
| study type: | b cell assays |
| subject species: | Escherichia coli |
| fullName: |
Hariharan Jayaram
Alessio Accardi
Fang Wu
Carole Williams
Christopher Miller
|
| method: |
x-ray crystallography
|
| name: |
Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger.
|
| description: |
The epitope residues are calculated from the PDB structure as the antigen residues at 4 Å
distance from the antibody.
The epitope of the Fab on the CLC-ec1 E148A/Y445A mutant transporter was determined from the crystal structure of the complex, solved by molecular replacement. The CLCec-1 transporter is a homodimer bound to two Fab molecules by identical epitopes, each located on both subunits of the homodimer.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
