Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1852365 |
| description: |
epitope description:D70, A71, Y74, T86, K89, L92, L93, E94, Q96, V97, L100, E101,G103, E112, I115, N119, N120, S123, C136, E137, E141
antigen name:Interleukin-15
host organism:Homo sapiens
antibody name:DISC0280
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21167836 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1021687 |
| landingPage: |
http://www.iedb.org/assay/1852365 |
| type: |
Literature
|
| publicationVenue: |
J Mol Biol
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
David C Lowe
Stefan Gerhardt
Alison Ward
David Hargreaves
Malcolm Anderson
Franco Ferraro
Richard A Pauptit
Debbie V Pattison
Catriona Buchanan
Bojana Popovic
Donna K Finch
Trevor Wilkinson
Matthew Sleeman
Tristan J Vaughan
Philip R Mallinder
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an alpha-helix in VH CDR3 as key component of paratope.
|
| description: |
The epitope specific antibody DISC0280 bound to IL-15 with a 288-fold increase in affinity compared to the parent antibody DISC0100.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
