Brain-reactive autoantibodies prevalent in human sera increase intraneuronal amyloid-beta(1-42) deposition.

Title:

Brain-reactive autoantibodies prevalent in human sera increase intraneuronal amyloid-beta(1-42) deposition.

identifier:	1852638
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Oryctolagus cuniculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	21483091

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Robert G Nagele Peter M Clifford Gilbert Siu Eli C Levin Nimish K Acharya Min Han Mary C Kosciuk Venkat Venkataraman Semah Zavareh Shabnam Zarrabi Kristin Kinsler Nikhil G Thaker Eric P Nagele Jacqueline Dash Hoau Y Wang Andrew Levitas

method:	immuno staining

name:	Brain-reactive autoantibodies prevalent in human sera increase intraneuronal amyloid-beta(1-42) deposition.
description:	To investigate a possible interrelationship between neuronal antibody binding and Amyloid beta pathology, the effects of human serum autoantibodies on the intraneuronal deposition of soluble epitope in adult mouse neurons in vitro (organotypic brain slice cultures) were tested. Binding of human autoantibodies to mouse neurons dramatically increased the rate and extent of intraneuronal epitope accumulation in the mouse cerebral cortex and hippocampus.

name:	iedb
homePage:	http://www.iedb.org

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