Identification and characterization of a cross-neutralization epitope of Enterovirus 71. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Identification and characterization of a cross-neutralization epitope of Enterovirus 71.

Dataset

identifier:	1853156
description:	epitope description:FGEHKQEKDLEYGAC antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:E1
aggregation:	instance of dataset
availability:	available
primaryPublications:	21501643

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022362
landingPage:	http://www.iedb.org/assay/1853156

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2011

Dimension

study type:	b cell assays
subject species:	Human enterovirus 71 Subgenogroup C2

Person

fullName:	Chia-Chyi Liu Ai-Hsiang Chou Shu-Pei Lien Hsiao-Yu Lin Shih-Jen Liu Jui-Yuan Chang Meng-Shin Guo Yen-Hung Chow Wun-Syue Yang Kate Hsuen-Wen Chang Charles Sia Pele Chong

Data Type

method:	antigen inhibition

Study

name:	Identification and characterization of a cross-neutralization epitope of Enterovirus 71.
description:	The epitope inhibited neutralization of EV71 strain E59 by the mAb. The epitope was also bound in direct ELISA. Scanning alanine mutagenesis revealed that residues K6, E6, K7, and D8 were critical for recognition by the mAb.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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