Surface plasmon resonance analysis of antipolysaccharide antibody specificity: responses to meningococcal group C conjugate vaccines and bacteria.

Title:

Surface plasmon resonance analysis of antipolysaccharide antibody specificity: responses to meningococcal group C conjugate vaccines and bacteria.

Dataset

identifier:	1853196
description:	epitope description:[9)-alpha-Neu5,7,8Ac3-(2->]n antigen name:polysaccharide host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	15155652

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/317
landingPage:	http://www.iedb.org/assay/1853196

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2004

Dimension

study type:	b cell assays
subject species:	Neisseria meningitidis serogroup C strain C11

Person

fullName:	Pablo A Garcí a-Ojeda Sharon Hardy Steven Kozlowski Kathryn E Stein Ian M Feavers

Data Type

method:	ELISA

Study

name:	Surface plasmon resonance analysis of antipolysaccharide antibody specificity: responses to meningococcal group C conjugate vaccines and bacteria.
description:	The meningococcal group C capsular PS (MCPS) is a linear homopolymer of alpha-(2-9)-linked sialic acid residues that are O-acetylated at carbons 7 and/or 8. Immunization with bacteria actually depleted the naturally occuring anti-epitope antibodies found in non-immune control mice when tested by fluorescence ELISA. A very low response could be detected by SPR.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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