Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1853589 |
| description: |
epitope description:R108, N109, V110, G111, S112, Q113, L115, N180, I185, N189, S236, S237, R239, P240, G241, I242, L244, W245, H246
antigen name:Integrin alpha-IIb
host organism:Mus musculus BALB/c
antibody name:10E5
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
20679525 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022168 |
| landingPage: |
http://www.iedb.org/assay/1853589 |
| type: |
Literature
|
| publicationVenue: |
Blood
|
| dates: |
2010
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Jieqing Zhu
Jianghai Zhu
Ana Negri
Davide Provasi
Marta Filizola
Barry S Coller
Timothy A Springer
|
| method: |
x-ray crystallography
|
| name: |
Closed headpiece of integrin alphaIIbbeta3 and its complex with an alphaIIbbeta3-specific antagonist that does not induce opening.
|
| description: |
The epitope of Fab 10E5 on integrin alphaIIbß3 was determined from the crystal structure of the complex in the absence of ligand and in the presence of 5 mM Mg2+. Fab 10E5 binds solely to the alphaIIb cap subdomain and has no effect on its conformation.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
