Sequence changes at the V-D junction of the VH1 heavy chain of anti-phosphocholine antibodies alter binding to and protection against Streptococcus pneumoniae.

Title:

Sequence changes at the V-D junction of the VH1 heavy chain of anti-phosphocholine antibodies alter binding to and protection against Streptococcus pneumoniae.

Dataset

identifier:	1853616
description:	epitope description:phosphocholine host organism:Mus musculus CBA/CaHN-Btkxid/J antibody name:31-34-2
aggregation:	instance of dataset
availability:	available
primaryPublications:	9184912

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007869
landingPage:	http://www.iedb.org/assay/1853616

Publication

type:	Literature
publicationVenue:	Int Immunol
dates:	1997

Dimension

study type:	b cell assays
subject species:	Streptococcus pneumoniae

Person

fullName:	W X Guo A M Burger R T Fischer D G Sieckmann D L Longo J J Kenny

Data Type

method:	antigen inhibition (~ IC50)

Study

name:	Sequence changes at the V-D junction of the VH1 heavy chain of anti-phosphocholine antibodies alter binding to and protection against Streptococcus pneumoniae.
description:	The epitope-specific mAb was obtained from Xid mice immunized with the thymus-dependent EPC-KLH conjugate. The epitope inhibited the reactivity to EPC-BSA in ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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