Sequence changes at the V-D junction of the VH1 heavy chain of anti-phosphocholine antibodies alter binding to and protection against Streptococcus pneumoniae.

Title:

Sequence changes at the V-D junction of the VH1 heavy chain of anti-phosphocholine antibodies alter binding to and protection against Streptococcus pneumoniae.

Dataset

identifier:	1853627
description:	epitope description:6-(O-phosphocholine)oxyhexanoate host organism:Mus musculus CBA/CaHN-Btkxid/J antibody name:31-34-2
aggregation:	instance of dataset
availability:	available
primaryPublications:	9184912

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007869
landingPage:	http://www.iedb.org/assay/1853627

Publication

type:	Literature
publicationVenue:	Int Immunol
dates:	1997

Dimension

study type:	b cell assays
subject species:

Person

fullName:	W X Guo A M Burger R T Fischer D G Sieckmann D L Longo J J Kenny

Data Type

method:	antigen inhibition (~ IC50)

Study

name:	Sequence changes at the V-D junction of the VH1 heavy chain of anti-phosphocholine antibodies alter binding to and protection against Streptococcus pneumoniae.
description:	p-nitrophenylphosphocholine (NPPC)-specific mAbs were obtained from Xid mice, which normally fail to produce anti-phosphocholine (PC) antibodies, when immunized with the epitope-KLH conjugate. NPPC inhibited the binding of the mAb to EPC-BSA in ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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