Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1853705 |
| description: |
epitope description:L51, P93, R140, P143, G144, H145, K148, E152, E157, F160, K176, E177, D178, E179, L180, G181, D182, R183, M186
antigen name:Interleukin-18
host organism:Mus musculus BALB/c
antibody name:125-2H
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
19553661 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1016492 |
| landingPage: |
http://www.iedb.org/assay/1853705 |
| type: |
Literature
|
| publicationVenue: |
J Biol Chem
|
| dates: |
2009
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Maria A Argiriadi
Tao Xiang
Chengbin Wu
Tariq Ghayur
David W Borhani
|
| method: |
x-ray crystallography
|
| name: |
Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18.
|
| description: |
The epitope residues are calculated from [PDB: 2VXT] as the antigen residues at he 4Å
atomic distance from the antibody.
The crystal structure of the epitope-specific monoclonal antibody binding to IL-18 was determined. The five cysteine residues in IL-18 were mutated to alanine.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
