Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/596 |
| landingPage: |
http://www.iedb.org/assay/1853714 |
| type: |
Literature
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| publicationVenue: |
Infect Immun
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| dates: |
2005
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| study type: | b cell assays |
| subject species: |
| fullName: |
Ulrike K Buchwald
Andrew Lees
Michael Steinitz
Liise-Anne Pirofski
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| method: |
ELISA
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| name: |
A peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice.
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| description: |
Type 8 PS-specific IgG in the PUB1 conjugate-immunized mice appeared between days 7 and 14. The response of the group that received the adjuvants was more rapid than that of the one that did not. The PUB1-TT/CpG-Al group showed a titer of 1:2,600 on day 14 and a peak titer of 1:3,000 at day 28. The PUB1-TT group not receiving adjuvants had a slower increase of type 8 PS-specific IgG, with a peak titer of 1/2,200 on day 49. Following day 49, the titers decreased in both groups but remained 6- to 11-fold above baseline values. IgG3 dominated the early type 8 PS-specific response, but IgG1 titers increased over time. In the PUB1-TT group, type 8 PS-specific IgG2a titers were below the lowest tested serum dilution (1:150) at most times. CpG-Al was associated with higher proportions of type 8 PS-specific IgG2a and IgG3.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
