Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.

Title:

Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.

identifier:	1854999
description:	epitope description:I224, E257, K278, N295 antigen name:Bla g 2 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	21789239

study type:	b cell assays
subject species:	Blattella germanica

fullName:	Jill Glesner Sabina Wü nschmann Mi Li Alla Gustchina Alexander Wlodawer Martin Himly Martin D Chapman Anna Pomé s

method:	ELISA

name:	Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.
description:	The epitopic residues were shown to be important for allergic patients' IgE binding because single alanine Bla g 2 mutant K251A or mutant E233R-I199W-N268Q displayed reduced IgE binding. The N-linked carbohydrate added to residue N268 has been shown to be involved in IgE and mAb binding.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.