Immunological Data Discovery Index
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identifier: 1862471
description:
epitope description:N54, C293, I294, T334, I363, D364, G365, W366, L383, K384, T386, Q387, A388, I390, D391, I393, N394, N398, I401, E402
antigen name:Hemagglutinin
host organism:Homo sapiens
antibody name:F16v3
aggregation:
instance of dataset
availability:
available
primaryPublications: 21798894
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1022352
landingPage: http://www.iedb.org/assay/1862471
type:
Literature
publicationVenue:
Science
dates:
2011
study type: b cell assays
subject species: Influenza A virus (A/Aichi/2/1968(H3N2))
fullName:
Davide Corti
Jarrod Voss
Steven J Gamblin
Giosiana Codoni
Annalisa Macagno
David Jarrossay
Sebastien G Vachieri
Debora Pinna
Andrea Minola
Fabrizia Vanzetta
Chiara Silacci
Blanca M Fernandez-Rodriguez
Gloria Agatic
Siro Bianchi
Isabella Giacchetto-Sasselli
Lesley Calder
Federica Sallusto
Patrick Collins
Lesley F Haire
Nigel Temperton
Johannes P M Langedijk
John J Skehel
Antonio Lanzavecchia
method:
ELISA
name:
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins.
description:
Chain A is HA1 and chain B is HA2 of hemagglutinin. The epitope residues are calculated from [PDB: 3ZTJ] as the antigen residues at 4 Å
atomic distance from the antibody.
Epitope-reactive antibody F16v3 bound to all recombinant or purified HAs tested belonging to group 1 (H1, H2, H5, H6, H8, H9 and H13) and group 2 ( H3, H4, H7, and H10).

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