Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.

Title:

Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.

identifier:	1859297
description:	epitope description:ANPSEKNSP antigen name:B-lymphocyte antigen CD20 host organism:Mus musculus antibody name:GA101, B-Ly1, H299/B1
aggregation:	instance of dataset
availability:	available
primaryPublications:	21444918

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Gerhard Niederfellner Alfred Lammens Olaf Mundigl Guy J Georges Wolfgang Schaefer Manfred Schwaiger Andreas Franke Kornelius Wiechmann Stefan Jenewein Jerry W Slootstra Peter Timmerman Annika Brä nnströ m Frida Lindstrom Ekkehard Mö ssner Pablo Umana Karl-Peter Hopfner Christian Klein

method:	flow cytometry

name:	Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.
description:	The epitope-reactive GA101 mAb bound to CD20 transfected into Freestyle 293-F cells. Binding was not significantly affected by mutation of residue Asn171, whereas Ala substitution of Asn176 reduced binding. GA101 also bound to CD20 on Z138, Ramos and normal B cells and induced an accumulation of GA101-CD20 complexes at sites of cell-cell contact.

name:	iedb
homePage:	http://www.iedb.org

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