Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.

Title:

Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.

identifier:	1859301
description:	epitope description:ANPS antigen name:B-lymphocyte antigen CD20 host organism:Mus musculus antibody name:Rituximab
aggregation:	instance of dataset
availability:	available
primaryPublications:	21444918

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Gerhard Niederfellner Alfred Lammens Olaf Mundigl Guy J Georges Wolfgang Schaefer Manfred Schwaiger Andreas Franke Kornelius Wiechmann Stefan Jenewein Jerry W Slootstra Peter Timmerman Annika Brä nnströ m Frida Lindstrom Ekkehard Mö ssner Pablo Umana Karl-Peter Hopfner Christian Klein

method:	calorimetry

name:	Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.
description:	The KD of epitope-specific Rituximab mAb binding to the cyclic peptide CD20 163-187 was measured at 15ºC. Because of its low affinity, the KD could not be measured at higher temperatures.

name:	iedb
homePage:	http://www.iedb.org

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