Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.

Dataset

identifier:	1859371
description:	epitope description:CGADSYEMEEDGVRKC + OX(C1, C16) antigen name:Epidermal growth factor receptor host organism:Mus musculus BALB/c antibody name:mAb806
aggregation:	instance of dataset
availability:	available
primaryPublications:	19289842

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1018806
landingPage:	http://www.iedb.org/assay/1859371

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2009

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Thomas P J Garrett Antony W Burgess Hui K Gan Rod B Luwor Glenn Cartwright Francesca Walker Suzanne G Orchard Andrew H A Clayton Edouard C Nice Julie Rothacker Bruno Catimel Webster K Cavenee Lloyd J Old Elisabeth Stockert Gerd Ritter Timothy E Adams Peter A Hoyne Dane Wittrup Ginger Chao Jennifer R Cochran Cindy Luo Mezhen Lou Trevor Huyton Yibin Xu W Douglas Fairlie Shenggen Yao Andrew M Scott Terrance G Johns

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.
description:	The epitope has a disulfide bond between cysteine residues at positions 1 and 16. MAb175 bound to the full-length extracellular domain of EGFR (1-621) with lower affinity (KD = 389 nM) than to the truncated EGFR (1-501) (KD = 34 nM), which cannot form the tethered form. MAb also bound to EGFR fragments

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.