Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1861897 |
| description: |
epitope description:A: H45, S46, S306, T333; B: V362, D363, G364, W365, L382, K385, T386, Q387, N388, I389, D390, T393, N397, I400, E401
antigen name:Hemagglutinin
host organism:Homo sapiens
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21798894 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022352 |
| landingPage: |
http://www.iedb.org/assay/1861897 |
| type: |
Literature
|
| publicationVenue: |
Science
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/California/04/2009(H1N1)) |
| fullName: |
Davide Corti
Jarrod Voss
Steven J Gamblin
Giosiana Codoni
Annalisa Macagno
David Jarrossay
Sebastien G Vachieri
Debora Pinna
Andrea Minola
Fabrizia Vanzetta
Chiara Silacci
Blanca M Fernandez-Rodriguez
Gloria Agatic
Siro Bianchi
Isabella Giacchetto-Sasselli
Lesley Calder
Federica Sallusto
Patrick Collins
Lesley F Haire
Nigel Temperton
Johannes P M Langedijk
John J Skehel
Antonio Lanzavecchia
|
| method: |
in vivo assay
|
| name: |
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins.
|
| description: |
Chain A is HA1 and chain B is HA2 of hemagglutinin. The epitope residues are calculated from [PDB: 3ZTN] as the antigen residues at 4 Å
atomic distance from the antibody.
Passive transfer of 4, 8, or 16 mg/kg of body weight of epitope-specific antibody F16v3 protected mice lethally infected with A/Puerto Rico/8/1934(H1N1) virus. Therapeutic administration of 15 mg/kg 1-2 days post-infection was also protective. Passive transfer of Fv163 reduced lung virus titers and reduced body weight loss.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
