Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022352 |
| landingPage: |
http://www.iedb.org/assay/1861905 |
| type: |
Literature
|
| publicationVenue: |
Science
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/Vietnam/1194/2004(H5N1)) |
| fullName: |
Davide Corti
Jarrod Voss
Steven J Gamblin
Giosiana Codoni
Annalisa Macagno
David Jarrossay
Sebastien G Vachieri
Debora Pinna
Andrea Minola
Fabrizia Vanzetta
Chiara Silacci
Blanca M Fernandez-Rodriguez
Gloria Agatic
Siro Bianchi
Isabella Giacchetto-Sasselli
Lesley Calder
Federica Sallusto
Patrick Collins
Lesley F Haire
Nigel Temperton
Johannes P M Langedijk
John J Skehel
Antonio Lanzavecchia
|
| method: |
in vivo assay
|
| name: |
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins.
|
| description: |
The epitope was deduced.
Passive transfer of 10 mg/kg of body weight of epitope-reactive antibody F16 protected mice lethally infected with A/Puerto Rico/8/1934(H1N1) virus. Passive transfer of F16 also reduced body weight loss. Fc mutants of F16 that lacked complement binding were fully protective, whereas F16 mutants that lacked complement and Fc receptor binding protected only 40% of the animals.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
