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Title: Antibody-mediated neutralization of cytomegalovirus: modulation of efficacy induced through the IgG constant region.
identifier: 1862013
description:
epitope description:ANETIYNTTLKYGDVVGVNT
antigen name:Envelope glycoprotein B
host organism:Homo sapiens
antibody name:ITC88
aggregation:
instance of dataset
availability:
available
primaryPublications: 11922941
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1004722
landingPage: http://www.iedb.org/assay/1862013
type:
Literature
publicationVenue:
Mol Immunol
dates:
2002
study type: b cell assays
subject species: Human herpesvirus 5 strain AD169
fullName:
Christina Furebring
Andrea Speckner
Michael Mach
Inger Sandlie
Lars Norderhaug
Carl A K Borrebaeck
Helé
ne Turesson
Mats Ohlin
method:
surface plasmon resonance (SPR)
name:
Antibody-mediated neutralization of cytomegalovirus: modulation of efficacy induced through the IgG constant region.
description:
The epitope sequence was obtained from Meyer et al., J Gen Virol. 1992. 73: 2375-2383. [PMID: 1383409] and Ohlin et al., J Virol. 1993 Feb
67(2):703-10 [PMID: 7678304].
The IgG1 version of the epitope-specific Ab was much less efficient than both the IgG3 and IgG3mA variants in binding C1q over a wide range of antibody densities as accessed by Biocore analysis.

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