Synthetic 6B di-, tri-, and tetrasaccharide-protein conjugates contain pneumococcal type 6A and 6B common and 6B-specific epitopes that elicit protective antibodies in mice.

Title:

Synthetic 6B di-, tri-, and tetrasaccharide-protein conjugates contain pneumococcal type 6A and 6B common and 6B-specific epitopes that elicit protective antibodies in mice.

Dataset

identifier:	1862816
description:	epitope description:alpha-L-Rhap-(1->4)-D-ribitol-(5-P-2)-alpha-D-Galp-(1->3)-alpha-D-Glcp antigen name:polysaccharide host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	11159969

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011686
landingPage:	http://www.iedb.org/assay/1862816

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2001

Dimension

study type:	b cell assays
subject species:	Streptococcus pneumoniae type 6B

Person

fullName:	W T Jansen S Hogenboom M J Thijssen J P Kamerling J F Vliegenthart J Verhoef H Snippe A F Verheul

Data Type

method:	antigen inhibition

Study

name:	Synthetic 6B di-, tri-, and tetrasaccharide-protein conjugates contain pneumococcal type 6A and 6B common and 6B-specific epitopes that elicit protective antibodies in mice.
description:	Polysaccharide (PS) from S. pneumoniae type 6B inhibited the binding of anti-epitope sera to type 6B PS. Anti-epitope sera also bound type 6B PS in direct ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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