Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutations.

Title:

Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutations.

Dataset

identifier:	1863327
description:	epitope description:L438 antigen name:Genome polyprotein host organism:Homo sapiens antibody name:CH-11
aggregation:	instance of dataset
availability:	available
primaryPublications:	21813602

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022478
landingPage:	http://www.iedb.org/assay/1863327

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2011

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus

Person

fullName:	Zhen-Yong Keck Anasuya Saha Jinming Xia Yong Wang Patrick Lau Thomas Krey Felix A Rey Steven K H Foung

Data Type

method:	immuno staining

Study

name:	Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutations.
description:	The epitope-specific mAb bound HCV-2a-infected cells by IFA. Mutation of the epitopic residues resulted in loss of binding and revealed critical residues. Double mutations including L438 plus T435 and L438 and N434 also decreased activity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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