Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutations.

Title:

Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutations.

Dataset

identifier:	1863325
description:	epitope description:D431, A439 antigen name:Genome polyprotein host organism:Homo sapiens antibody name:CBH-2
aggregation:	instance of dataset
availability:	available
primaryPublications:	21813602

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022478
landingPage:	http://www.iedb.org/assay/1863325

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2011

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus

Person

fullName:	Zhen-Yong Keck Anasuya Saha Jinming Xia Yong Wang Patrick Lau Thomas Krey Felix A Rey Steven K H Foung

Data Type

method:	biological activity

Study

name:	Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutations.
description:	The epitope-specific mAb neutralized HCV-2a-infected cells. Mutational analysis resulting in loss of neutralization was used to identify critical residues.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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