Rational development of high-affinity T-cell receptor-like antibodies. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Rational development of high-affinity T-cell receptor-like antibodies.

Dataset

identifier:	1863511
description:	epitope description:R89, K90, A93, Q96, T97, A174, Q179 antigen name:HLA class I histocompatibility antigen, A-2 alpha chain host organism:Homo sapiens antibody name:3M4F4
aggregation:	instance of dataset
availability:	available
primaryPublications:	19307587

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019713
landingPage:	http://www.iedb.org/assay/1863511

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2009

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Guillaume Stewart-Jones Andreas Wadle Anja Hombach Eugene Shenderov Gerhard Held Eliane Fischer Sascha Kleber Natko Nuber Frank Stenner-Liewen Stefan Bauer Andrew McMichael Alexander Knuth Hinrich Abken Andreas A Hombach Vincenzo Cerundolo E Yvonne Jones Christoph Renner

Data Type

method:	x-ray crystallography

Study

name:	Rational development of high-affinity T-cell receptor-like antibodies.
description:	The epitope of Fab 3M4F4 on the NY-ESO-1(157-165)/HLA-A*0201 complex was determined from the crystal structure, solved by molecular replacement. The NY-ESO-1(157-165) peptide analog with a C9V substitution was used. Fab 3M4F4 contacts the HLA-A2 molecule (chain A) and the peptide (chain C).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.