Rational development of high-affinity T-cell receptor-like antibodies. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Rational development of high-affinity T-cell receptor-like antibodies.

Dataset

identifier:	1863516
description:	epitope description:SLLMWITQV host organism:Homo sapiens antibody name:3M4E5
aggregation:	instance of dataset
availability:	available
primaryPublications:	19307587

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019713
landingPage:	http://www.iedb.org/assay/1863516

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2009

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Guillaume Stewart-Jones Andreas Wadle Anja Hombach Eugene Shenderov Gerhard Held Eliane Fischer Sascha Kleber Natko Nuber Frank Stenner-Liewen Stefan Bauer Andrew McMichael Alexander Knuth Hinrich Abken Andreas A Hombach Vincenzo Cerundolo E Yvonne Jones Christoph Renner

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Rational development of high-affinity T-cell receptor-like antibodies.
description:	The epitope-reactive Fab 3M4E5 bound to the epitope/HLA-A*0201 complex with moderate affinity. The affinity for the complex containing the natural peptide NY-ESO-1(157-165) with a Cys at position 9 or the analog peptide with a Val at position 9 were similar, KD = 47 versus 46 nM, respectively.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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