Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022579 |
| landingPage: |
http://www.iedb.org/assay/1898638 |
| type: |
Literature
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| publicationVenue: |
J Toxicol Environ Health A
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| dates: |
2011
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| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Xiaochen Zhou
Hao Bi
Justin Wong
Miyuki Shimoji
Yifan Wang
Jue Yuan
Xiangzhu Xiao
Gong-Xian Wang
Wen-Quan Zou
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| method: |
western blot
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| name: |
Alkylating antitumor drug mechlorethamine conceals a structured PrP domain and inhibits in vitro prion amplification.
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| description: |
The effect of alkylating antitumor drugs (mechlorethamine, doxorubicin, and streptozotocin) on the antibody accessibility of PrP epitopes that could be involved in the conversion of PrPc to PrPSc was examined. After treatment with different amounts of the drugs in the presence of the reducing reagent TBP, the antisera detected PrP in normal human brain homogenates.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |
