Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1016460 |
| landingPage: |
http://www.iedb.org/assay/1898647 |
| type: |
Literature
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| publicationVenue: |
Proc Natl Acad Sci U S A
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| dates: |
2009
|
| study type: | b cell assays |
| subject species: |
| fullName: |
M Britschgi
C E Olin
H T Johns
Y
M C LeMieux
K Rufibach
J Rajadas
H Zhang
B Tomooka
W H Robinson
C M Clark
A M Fagan
D R Galasko
D M Holtzman
M Jutel
J A Kaye
C A Lemere
J Leszek
G Li
E R Peskind
J F Quinn
J A Yesavage
J A Ghiso
|
| method: |
microarray
|
| name: |
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.
|
| description: |
The natural epitope comprises aa1-22 [EASNCFAIRHFENKFAVETLIC].
Human IgG reactivities against peptides preparations were measured with antigen microarrays in plasma from healthy female subjects ages 21-85. Antibody reactivities against several amyloidogenic beta amyloid mutant and non-beta amyloid peptides (oligomeric forms) are reduced with age.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
