Developing subunit immunogens using B and T cell epitopes and their constructs derived from the F1 antigen of Yersinia pestis using novel delivery vehicles.

Title:

Developing subunit immunogens using B and T cell epitopes and their constructs derived from the F1 antigen of Yersinia pestis using novel delivery vehicles.

Dataset

identifier:	1865652
description:	epitope description:TGSQDFFVRSIG antigen name:F1 capsule antigen host organism:Mus musculus FVB/J antibody name:Serum
aggregation:	instance of dataset
availability:	available
primaryPublications:	14522457

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1224
landingPage:	http://www.iedb.org/assay/1865652

Publication

type:	Literature
publicationVenue:	FEMS Immunol Med Microbiol
dates:	2003

Dimension

study type:	b cell assays
subject species:	Yersinia pestis

Person

fullName:	Leenu Sabhnani Monika Manocha Kurella Sridevi Donthamsetty Shashikiran Ravi Rayanade Donthamsetty Nageswara Rao

Data Type

method:	ELISA

Study

name:	Developing subunit immunogens using B and T cell epitopes and their constructs derived from the F1 antigen of Yersinia pestis using novel delivery vehicles.
description:	Immunization with the epitope using liposomes adjuvant produced a stronger response than alhydrogel adjuvant. H-2b, H-2d, H-2k and H-2q mice all produced a positive response. All mice strains showed very high IgG1, IgG2a and IgG2b Ab levels, but IgG3 level was negligible. Mice immunized with a peptide conjugate containing the epitope produced the highest response 42 days after immunization.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.