A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.

Title:

A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.

Dataset

identifier:	1866374
description:	epitope description:T31, C33, G34, G35, E36, V38, D39, L41, F50, R58, V59, R64, V67, E68, E69, C71, F72, R73, Y83 antigen name:Insulin-like growth factor II host organism:Homo sapiens antibody name:DX-2647
aggregation:	instance of dataset
availability:	available
primaryPublications:	20515953

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019666
landingPage:	http://www.iedb.org/assay/1866374

Publication

type:	Literature
publicationVenue:	Mol Cancer Ther
dates:	2010

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Daniel T Dransfield Edward H Cohen Qing Chang Lindsay G Sparrow John D Bentley Olan Dolezal Xiaowen Xiao Thomas S Peat Janet Newman Patricia A Pilling Tram Phan Ilka Priebe Gemma V Brierley Niksa Kastrapeli Kris Kopacz Diana Martik Dina Wassaf Douglas Rank Greg Conley Yan Huang Timothy E Adams Leah Cosgrove

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.
description:	Epitope residues are calculated from the structure [PDB: 3KR3] as the antigen residues at 4 Å distance from the antibody. The epitope specific optimized Fab DX-2647bound to IGF-II with high affinity. DX-2647 also bound to the E-domain COOH-terminal extension isoform of IGF-II (IGF-IIE) with high affinity, KD = 10 pM.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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