Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1866380 |
| description: |
epitope description:R155, R158, M159, K161, K162, L163, L164, V166, P167, A168, A169, N170, T171, V172, R173, R175, P177, K205, R207, Q210, V214, E216, Y241, R248, Y278, S279, D280, A281, Q282, P283, S314, E315, S316, V317, E318
antigen name:Fibroblast growth factor receptor 3
host organism:Homo sapiens
antibody name:R3Mab
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
19381019 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1019640 |
| landingPage: |
http://www.iedb.org/assay/1866380 |
| type: |
Literature
|
| publicationVenue: |
J Clin Invest
|
| dates: |
2009
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Jing Qing
Xiangnan Du
Yongmei Chen
Pamela Chan
Hao Li
Ping Wu
Scot Marsters
Scott Stawicki
Janet Tien
Klara Totpal
Sarajane Ross
Susanna Stinson
David Dornan
Dorothy French
Qian-Rena Wang
Jean-Philippe Stephan
Yan Wu
Christian Wiesmann
Avi Ashkenazi
|
| method: |
x-ray crystallography
|
| name: |
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.
|
| description: |
Epitope residues are calculated from the structure [PDB: 3GRW] as the antigen residues at 4 Å
distance from the antibody.
The epitope of R3Mab Fab on FGF receptor 3-IIIb extracellular IgD2-D3 region was determined from the crystal structure of the complex, solved by molecular replacement.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
