Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies.

Title:

Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies.

identifier:	1884019
description:	epitope description:E53, N64, T65, D66, D70, Q75, I76, N77, R79, W80, W81, R91, I116, N121, N124, A125, W126, V127, R130 antigen name:Gal d 4 host organism:Camelus dromedarius antibody name:cABCII10-L-L-L.
aggregation:	instance of dataset
availability:	available
primaryPublications:	16095608

study type:	b cell assays
subject species:	Gallus gallus

fullName:	Dirk Saerens Mireille Pellis Remy Loris Els Pardon Mireille Dumoulin André Matagne Lode Wyns Serge Muyldermans Katja Conrath

method:	x-ray crystallography

name:	Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies.
description:	Epitope residues are calculated from the structure [PDB: 1ZMY] as the antigen residues at 4 Å distance from the antibody. The epitope of the chimeric VHH cABCII10-L-L-L on hen egg white lysozyme (HEWL) was determined from the crystal structure of the complex, solved by molecular replacement.

name:	iedb
homePage:	http://www.iedb.org

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