Discontinuous epitopes on the C2 domain of coagulation Factor VIII mapped by computer-designed synthetic peptides.

Title:

Discontinuous epitopes on the C2 domain of coagulation Factor VIII mapped by computer-designed synthetic peptides.

identifier:	1884231
description:	epitope description:WVHQYKE host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	21933172

study type:	b cell assays
subject species:

fullName:	Auré lien Lebreton Violaine Moreau Priscilla Lapalud Christopher Cayzac Sé bastien André Christophe Nguyen Jean-Franç ois Schved Gé raldine Lavigne Claude Granier

method:	antigen inhibition

name:	Discontinuous epitopes on the C2 domain of coagulation Factor VIII mapped by computer-designed synthetic peptides.
description:	This epitope mimics predicted discontinuous epitopes of Factor VIII. The epitope was able to inhibit binding of the patient's plasma to the C2 domain of Factor VIII. The epitope sequence was C-terminally extended with an aminohexanoic acid-Tyr-Gly spacer, and N- and C-terminally acetylated.

name:	iedb
homePage:	http://www.iedb.org

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