Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.

Title:

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.

identifier:	1885305
description:	epitope description:G147, V148, S149, A150, W166, T168, G169, N171, G172, L173, N200, I201, G202, D203, R205, A206, L207, K235, D238, R239 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:CH65
aggregation:	instance of dataset
availability:	available
primaryPublications:	21825125

study type:	b cell assays
subject species:	Influenza A virus (A/Solomon Islands/3/2006(H1N1))

fullName:	James R R Whittle Ruijun Zhang Surender Khurana Lisa R King Jody Manischewitz Hana Golding Philip R Dormitzer Barton F Haynes Emmanuel B Walter M Anthony Moody Thomas B Kepler Hua-Xin Liao Stephen C Harrison

method:	biological activity

name:	Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.
description:	Epitope residues are calculated from the structure [PDB: 35UGY] as the antigen residues (PDB chain A) at 4 Å distance from the antibody (PDB chains H and L). The epitope-specific mAb CH65 neutralized 30 of 36 strains of Influenza A virus tested, as determined in a micro-neutralization assay using Madin Darby canine kidney cells.

name:	iedb
homePage:	http://www.iedb.org

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