Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice.

Title:

Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice.

identifier:	1898799
description:	epitope description:SAVSRPMIHFGNDWEDRYYRENMY antigen name:Major prion protein host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	22008817

study type:	b cell assays
subject species:	Mus musculus

fullName:	Daisuke Ishibashi Hitoki Yamanaka Tsuyoshi Mori Naohiro Yamaguchi Yoshitaka Yamaguchi Noriyuki Nishida Suehiro Sakaguchi

method:	ELISA

name:	Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice.
description:	The epitope sequence is referenced in Ishibashi et al., Vaccine. 2007 Jan 22 25(6):985-92. [PMID: 17055125]. The ability of E. coli-derived succinylarginine dihydrolase, which has significant sequence homology to the protective mAb 6H4 epitope (WEDRYYRE, contained within PrP 131-154), to antigenically mimic the prion epitope and therefore offer anti-prion protection was examined. Immunization of mice with recombinant succinylarginine dihydrolase, induced anti-PrP antibodies detected by ELISA. This immunization was also shown to increase survival times of the mice subsequently infected with Fukuoka-1 prions. Similar results were obtained when succinylarginine dihydrolase from S. enterica subspecies enterica serovar Paratyphi A was used.

name:	iedb
homePage:	http://www.iedb.org

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